Anti-RAMP3 antibody (STJ193092)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Receptor activity-modifying protein 3 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAMP3 |
| Gene ID | 10268 |
| Uniprot ID | RAMP3_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | RAMP3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2. Together with CALCR, act as a receptor complex for amylin/IAPP. |
| Protein Name | Receptor Activity-Modifying Protein 3Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3Crlr Activity-Modifying Protein 3 |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembraneMoves From Intracellular Puncta To The Plasma Membrane In A Ramp3-Dependent Manner |
| Alternative Antibody Names | Anti-Receptor Activity-Modifying Protein 3 antibodyAnti-Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3 antibodyAnti-Crlr Activity-Modifying Protein 3 antibodyAnti-RAMP3 antibody |
Information sourced from Uniprot.org