Anti-RAMP3 antibody (1-118) (STJ28798)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RAMP3 (1-118) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAMP3 |
| Gene ID | 10268 |
| Uniprot ID | RAMP3_HUMAN |
| Immunogen Region | 1-118 |
| Immunogen Sequence | METGALRRPQLLPLLLLLCG GCPRAGGCNETGMLERLPLC GKAFADMMGKVDVWKWCNLS EFIVYYESFTNCTEMEANVV GCYWPNPLAQGFITGIHRQF FSNCTVDRVHLEDPPDEV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RAMP3 (NP_005847.1). |
Additional Info
| Tissue Specificity | Strongly expressed in lung, breast, immune system and fetal tissues. |
| Function | Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2. Together with CALCR, act as a receptor complex for amylin/IAPP. |
| Protein Name | Receptor Activity-Modifying Protein 3Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3Crlr Activity-Modifying Protein 3 |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembraneMoves From Intracellular Puncta To The Plasma Membrane In A Ramp3-Dependent Manner |
| Alternative Antibody Names | Anti-Receptor Activity-Modifying Protein 3 antibodyAnti-Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3 antibodyAnti-Crlr Activity-Modifying Protein 3 antibodyAnti-RAMP3 antibody |
Information sourced from Uniprot.org