| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RALB (1-206) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RALB |
| Gene ID: |
5899 |
| Uniprot ID: |
RALB_HUMAN |
| Immunogen Region: |
1-206 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RALB (NP_002872.1). |
| Immunogen Sequence: |
MAANKSKGQSSLALHKVIMV GSGGVGKSALTLQFMYDEFV EDYEPTKADSYRKKVVLDGE EVQIDILDTAGQEDYAAIRD NYFRSGEGFLLVFSITEHES FTATAEFREQILRVKAEEDK IPLLVVGNKSDLEERRQVPV EEARSKAEEWGVQYVETSAK TRANVDKVFFDLMREIRTKK MSENKDKNGKKSSKNKKSFK ERCCLL |
| Post Translational Modifications | Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs). The farnesylated form confers resistance to the proapoptotic and anti-anchorage-dependent growth effects of geranylgeranyltransferase I inhibitors, including GGTI-2417. |
| Function | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission. Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors. |
| Protein Name | Ras-Related Protein Ral-B |
| Database Links | Reactome: R-HSA-171007 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideMidbodyDuring Late CytokinesisEnriched At The Midbody |
| Alternative Antibody Names | Anti-Ras-Related Protein Ral-B antibodyAnti-RALB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
