Anti-RAIDD antibody [R01-3H6] (STJA0035865)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human RAIDD
General Information
| Short Description | Rabbit monoclonal anti-RAIDD for use in WB, IHC-P, ICC, IF, IP and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/IP/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-3H6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:50FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | CRADD |
| Gene ID | 8738 |
| Uniprot ID | CRADD_HUMAN |
| Immunogen | A synthesized peptide derived from human RAIDD |
Additional Info
| Tissue Specificity | Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney. |
| Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway. |
| Protein Name | Death Domain-Containing Protein CraddCaspase And Rip Adapter With Death DomainRip-Associated Protein With A Death Domain |
| Database Links | Reactome: R-HSA-6803207 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Death Domain-Containing Protein Cradd antibodyAnti-Caspase And Rip Adapter With Death Domain antibodyAnti-Rip-Associated Protein With A Death Domain antibodyAnti-CRADD antibodyAnti-RAIDD antibody |
Information sourced from Uniprot.org