Anti-Radixin antibody (350-450) [S3MR] (STJ11103113)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Radixin (350-450) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S3MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RDX |
| Gene ID | 5962 |
| Uniprot ID | RADI_HUMAN |
| Immunogen Region | 350-450 |
| Immunogen Sequence | RLKQIEEQTIKAQKELEEQT RKALELDQERKRAKEEAERL EKERRAAEEAKSAIAKQAAD QMKNQEQLAAELAEFTAKIA LLEEAKKKKEEEATEWQHKA F |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human Radixin (P35241). |
Additional Info
| Post Translational Modifications | Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. |
| Function | Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. |
| Protein Name | Radixin |
| Database Links | Reactome: R-HSA-437239Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeletonCleavage FurrowCell ProjectionMicrovillusStereociliumEnriched At The Stereocilium Base With Very Low Levels In The Shaft Of Stereociliary BundlesHighly Concentrated In The Undercoat Of The Cell-To-Cell Adherens Junction And The Cleavage Furrow In The Interphase And Mitotic PhaseRespectively |
| Alternative Antibody Names | Anti-Radixin antibodyAnti-RDX antibody |
Information sourced from Uniprot.org