| Host: |
Goat |
| Applications: |
WB |
| Reactivity: |
Human/Rat/Mouse/Monkey/Canine |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-RAB8B, member RAS oncogene family (107aa C-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Purification: |
This antibody is epitope-affinity purified from goat antiserum. |
| Concentration: |
3 mg/ml |
| Dilution Range: |
WB 1:250-1:1000 |
| Storage Instruction: |
For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
| Gene Symbol: |
RAB8B |
| Gene ID: |
51762 |
| Uniprot ID: |
RAB8B_HUMAN |
| Immunogen Region: |
107aa C-Term |
| Accession Number: |
ENSG00000166128 |
| Specificity: |
Detects Rab8b protein in transfected cells with GFP-Rab8b cds by Western blot. This Ab is specific for Rab8b. It does not recognize Rab8a. |
| Immunogen: |
Purified recombinant peptide derived from within residues 107 aa to the C-terminus of mouse Rab8b produced in E. coli. |
| Post Translational Modifications | Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells. May participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route. |
| Protein Name | Ras-Related Protein Rab-8b |
| Database Links | Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmic VesiclePhagosomePhagosome MembraneEndosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosisColocalized With Mical1Graf1/Arhgap26 And Graf2/Arhgap10 On Endosomal Tubules |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-8b antibodyAnti-RAB8B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
