Anti-RAB4B antibody (N-Term) (STJ13101933)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from n-terminal region of human Ras-related protein Rab-4B (RAB4B) conjugated to blue carrier protein has been used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-RAB4B (N-Term) for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. Use at a dilution of 1:100 to 1: 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | RAB4B |
| Gene ID | 53916 |
| Uniprot ID | RAB4B_HUMAN |
| Immunogen | A synthetic peptide from n-terminal region of human Ras-related protein Rab-4B (RAB4B) conjugated to blue carrier protein has been used as the antigen. |
| Immunogen Region | N-Term |
| Specificity | Specific for RAB4A. |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB4B mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB14. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets. |
| Protein Name | Ras-Related Protein Rab-4b |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8873719Reactome: R-HSA-8875656 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-4b antibodyAnti-RAB4B antibodyAnti-RAB4 antibodyAnti-PP1596 antibody |
Information sourced from Uniprot.org