| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Ras-related protein Rab-4A is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 3D1-A9-H10 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAB4A |
| Gene ID: | 5867 |
| Uniprot ID: | RAB4A_HUMAN |
| Specificity: | This antibody detects endogenous levels of RAB4A and does not cross-react with related proteins. |
| Immunogen: | Purified recombinant human RAB4A protein fragments expressed in E.coli. |
| Function | Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Involved in protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling. Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets. |
| Protein Name | Ras-Related Protein Rab-4a |
| Database Links | Reactome: R-HSA-1445148 Reactome: R-HSA-1660499 Reactome: R-HSA-8854214 Reactome: R-HSA-8873719 Reactome: R-HSA-8875656 |
| Cellular Localisation | Membrane Peripheral Membrane Protein Cytoplasm Early Endosome Membrane Recycling Endosome Membrane Generally Associated With Membranes Cytoplasmic When Phosphorylated By Cdk1 |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-4a antibody Anti-RAB4A antibody Anti-RAB4 antibody |
Information sourced from Uniprot.org