Anti-RAB3GAP2 antibody (417-466 aa) (STJ95292)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RAB3GAP2 at the amino acid range 417-466
General Information
| Short Description | Rabbit polyclonal anti-Rab3 GTPase-activating protein non-catalytic subunit (417-466 aa) for use in WB, IHC, IF and ELISA in Human, Mouse, Rat and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB3GAP2 |
| Gene ID | 25782 |
| Uniprot ID | RBGPR_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RAB3GAP2 at the amino acid range 417-466 |
| Immunogen Region | 417-466 aa |
| Specificity | Rab 3 GAP p150 Polyclonal Antibody detects endogenous levels of Rab 3 GAP p150 protein. |
Additional Info
| Function | Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18. As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3GAP complex acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. |
| Protein Name | Rab3 Gtpase-Activating Protein Non-Catalytic SubunitRgap-IsoRab3 Gtpase-Activating Protein 150 Kda SubunitRab3-Gap P150Rab3-Gap150Rab3-Gap Regulatory Subunit |
| Database Links | Reactome: R-HSA-6811436Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumIn NeuronsIt Is Enriched In The Synaptic Soluble Fraction |
| Alternative Antibody Names | Anti-Rab3 Gtpase-Activating Protein Non-Catalytic Subunit antibodyAnti-Rgap-Iso antibodyAnti-Rab3 Gtpase-Activating Protein 150 Kda Subunit antibodyAnti-Rab3-Gap P150 antibodyAnti-Rab3-Gap150 antibodyAnti-Rab3-Gap Regulatory Subunit antibodyAnti-RAB3GAP2 antibodyAnti-KIAA0839 antibody |
Information sourced from Uniprot.org