• Western blot analysis of various lysates using RAB3GAP2 Rabbit polyclonal antibody (STJ119718) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-RAB3GAP2 antibody (1-200) (STJ119718)

SKU:
STJ119718

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Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RAB3GAP2 (1-200) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RAB3GAP2
Gene ID: 25782
Uniprot ID: RBGPR_HUMAN
Immunogen Region: 1-200
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RAB3GAP2 (NP_036546.2).
Immunogen Sequence: MACSIVQFCYFQDLQAARDF LFPHLREEILSGALRRDPSK STDWEDDGWGAWEENEPQEP EEEGNTCKTQKTSWLQDCVL SLSPTNDLMVIAREQKAVFL VPKWKYSDKGKEEMQFAVGW SGSLNVEEGECVTSALCIPL ASQKRSSTGRPDWTCIVVGF TSGYVRFYTENGVLLLAQLL NEDPVLQLKCRTYEIPRHPG
Tissue Specificity Ubiquitous.
Function Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18. As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Required for recruiting and activating RAB18 at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.
Protein Name Rab3 Gtpase-Activating Protein Non-Catalytic Subunit
Rgap-Iso
Rab3 Gtpase-Activating Protein 150 Kda Subunit
Rab3-Gap P150
Rab3-Gap150
Rab3-Gap Regulatory Subunit
Database Links Reactome: R-HSA-6811436
Reactome: R-HSA-8876198
Cellular Localisation Cytoplasm
Endoplasmic Reticulum
In Neurons
It Is Enriched In The Synaptic Soluble Fraction
Alternative Antibody Names Anti-Rab3 Gtpase-Activating Protein Non-Catalytic Subunit antibody
Anti-Rgap-Iso antibody
Anti-Rab3 Gtpase-Activating Protein 150 Kda Subunit antibody
Anti-Rab3-Gap P150 antibody
Anti-Rab3-Gap150 antibody
Anti-Rab3-Gap Regulatory Subunit antibody
Anti-RAB3GAP2 antibody
Anti-KIAA0839 antibody

Information sourced from Uniprot.org

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