Anti-RAB39B antibody (80-160 aa) (STJ191284)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 80-160
General Information
| Short Description | Rabbit polyclonal anti-Ras-related protein Rab-39B (80-160 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB39B |
| Gene ID | 116442 |
| Uniprot ID | RB39B_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 80-160 |
| Immunogen Region | 80-160 aa |
| Specificity | RB39B Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB39B is involved in autophagy and may function in autophagosome formation. Binds downstream effector PICK1 to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR composition at the post-synapses and thus synaptic transmission. May regulate the homeostasis of SNCA/alpha-synuclein. |
| Protein Name | Ras-Related Protein Rab-39b |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmic Vesicle MembraneGolgi ApparatusCytoplasmic VesicleAutophagosome MembraneAutolysosome MembranePartial Colocalization With Markers That Cycle From The Cell Surface To The Trans-Golgi NetworkColocalized With Stx17 In Autolysosomes In Autophagy-Induced ConditionsAlthough Less Compared With Rab39a |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-39b antibodyAnti-RAB39B antibody |
Information sourced from Uniprot.org