| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RAB38 (92-211) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAB38 |
| Gene ID: |
23682 |
| Uniprot ID: |
RAB38_HUMAN |
| Immunogen Region: |
92-211 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 92-211 of human RAB38 (NP_071732.1). |
| Immunogen Sequence: |
VTRPATFEAVAKWKNDLDSK LSLPNGKPVSVVLLANKCDQ GKDVLMNNGLKMDQFCKEHG FVGWFETSAKENINIDEASR CLVKHILANECDLMESIEPD VVKPHLTSTKVASCSGCAKS |
| Tissue Specificity | Expressed in melanocytes. |
| Post Translational Modifications | Although at least one in vitro system can process and methylate the prenylated C-terminal, in an in vitro system that normally express Rab-38 and in vivo the prenylated C-terminal is not proteolytically processed and not methylated. |
| Function | May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes.the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. |
| Protein Name | Ras-Related Protein Rab-38Melanoma Antigen Ny-Mel-1 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideMelanosomeCytoplasmic VesiclePhagosomePhagosome MembraneMelanosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosisThe Bloc-3 ComplexA Heterodimer Of Hps1 And Hps4 Promotes Its Membrane Localization |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-38 antibodyAnti-Melanoma Antigen Ny-Mel-1 antibodyAnti-RAB38 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
