| Host: |
Goat |
| Applications: |
WB/IF |
| Reactivity: |
Human/Rat/Mouse/Monkey/Canine |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-RAB32, member RAS oncogene family (120aa C-Term) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Purification: |
This antibody is epitope-affinity purified from goat antiserum. |
| Concentration: |
4 mg/ml |
| Dilution Range: |
WB 1:500-1:2000IF 1:100-1:500 |
| Storage Instruction: |
For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
| Gene Symbol: |
RAB32 |
| Gene ID: |
10981 |
| Uniprot ID: |
RAB32_HUMAN |
| Immunogen Region: |
120aa C-Term |
| Accession Number: |
ENSG00000118508 |
| Specificity: |
Detects an endogenous band by Western blot in Melan-ink, XB2 and 3T3 cell line lysates (approximately 30 kDa) and in transfected cells with GFP-Rab32 cds. |
| Immunogen: |
Purified recombinant peptide derived from within residues 120 aa to the C-terminus of mouse Rab27a produced in E. coli. |
| Tissue Specificity | Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung. |
| Function | Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. |
| Protein Name | Ras-Related Protein Rab-32 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | MitochondrionMitochondrion Outer MembraneLipid-AnchorCytoplasmic VesiclePhagosomePhagosome MembraneCytoplasmic SideMelanosomeMelanosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosisThe Bloc-3 ComplexA Heterodimer Of Hps1 And Hps4 Promotes Its Membrane Localization |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-32 antibodyAnti-RAB32 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
