Anti-RAB31 antibody (95aa C-Term) (STJ140116)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
ImmunogenPurified recombinant peptide derived from within residues 95 aa to the C-terminus of mouse Rab31 produced in E. coli.
General Information
| Short Description | Goat polyclonal RAB31, member RAS oncogene family (95aa C-Term) antibody for use in WB in human, mouse, rat, bovine, canine, chicken, avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep and simian samples. Datasheet includ |
| Applications | WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Bovine/Canine/Chicken/Avian/Donkey/Feline/Goat/Guinea Pig/Hamster/Horse/Porcine/Rabbit/Sheep/Simian |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 3 mg/mL |
| Purification | This antibody is epitope-affinity purified from goat antiserum. |
| Dilution Range | WB 1:250-1:2000 |
| Formulation | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Storage Instruction | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
Target Information
| Gene Symbol | RAB31 |
| Gene ID | 11031 |
| Uniprot ID | RAB31_HUMAN |
| Accession Number | ENSG00000168461 |
| Immunogen | Purified recombinant peptide derived from within residues 95 aa to the C-terminus of mouse Rab31 produced in E. coli. |
| Immunogen Region | 95aa C-Term |
| Immunogen Sequence | KKWVKELKEHGPENIVMAIA KWVKELKEHGPENIVMAIAG WVKELKEHGPENIVMAIAGN VKELKEHGPENIVMAIAGNK KELKEHGPENIVMAIAGNKC |
| Specificity | Detects endogenous levels of Rab31 and in transfected cells with GFP-Rab31 by Western blot. |
Additional Info
| Tissue Specificity | Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. |
| Protein Name | Ras-Related Protein Rab-31Ras-Related Protein Rab-22b |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkTrans-Golgi Network MembraneLipid-AnchorCytoplasmic SideEarly EndosomeCytoplasmic VesiclePhagosomePhagosome MembraneRapidly Recruited To Phagosomes Containing SAureus Or MTuberculosis |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-31 antibodyAnti-Ras-Related Protein Rab-22b antibodyAnti-RAB31 antibodyAnti-RAB22B antibody |
Information sourced from Uniprot.org