Anti-RAB31 antibody (1-195) (STJ29642)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RAB31 (1-195) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB31 |
| Gene ID | 11031 |
| Uniprot ID | RAB31_HUMAN |
| Immunogen Region | 1-195 |
| Immunogen Sequence | MMAIRELKVCLLGDTGVGKS SIVCRFVQDHFDHNISPTIG ASFMTKTVPCGNELHKFLIW DTAGQERFHSLAPMYYRGSA AAVIVYDITKQDSFYTLKKW VKELKEHGPENIVMAIAGNK CDLSDIREVPLKDAKEYAES IGAIVVETSAKNAINIEELF QGISRQIPPLDPHENGNNGT IKVEKPTMQASRRCC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-195 of human RAB31 (NP_006859.2). |
Additional Info
| Tissue Specificity | Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. |
| Protein Name | Ras-Related Protein Rab-31Ras-Related Protein Rab-22b |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkTrans-Golgi Network MembraneLipid-AnchorCytoplasmic SideEarly EndosomeCytoplasmic VesiclePhagosomePhagosome MembraneRapidly Recruited To Phagosomes Containing SAureus Or MTuberculosis |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-31 antibodyAnti-Ras-Related Protein Rab-22b antibodyAnti-RAB31 antibodyAnti-RAB22B antibody |
Information sourced from Uniprot.org