Anti-RAB27A antibody (STJ13101936)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from human RAB27A conjugated to blue carrier protein has been used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-RAB27A for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. Use at a dilution of 1:300 to 1: 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | RAB27A |
| Gene ID | 5873 |
| Uniprot ID | RB27A_HUMAN |
| Immunogen | A synthetic peptide from human RAB27A conjugated to blue carrier protein has been used as the antigen. |
| Specificity | Specific for RAB27. |
Additional Info
| Function | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. |
| Protein Name | Ras-Related Protein Rab-27aRab-27Gtp-Binding Protein Ram |
| Database Links | Reactome: R-HSA-264876Reactome: R-HSA-6798695Reactome: R-HSA-8873719Reactome: R-HSA-8876198Reactome: R-HSA-9824585 |
| Cellular Localisation | MembraneLipid-AnchorMelanosomeLate EndosomeLysosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvLocalizes To Endosomal Exocytic Vesicles |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-27a antibodyAnti-Rab-27 antibodyAnti-Gtp-Binding Protein Ram antibodyAnti-RAB27A antibodyAnti-RAB27 antibody |
Information sourced from Uniprot.org