Anti-RAB24 antibody (STJ13101861)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptidefrom human RAB24 conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in mouse and rat.
General Information
| Short Description | Rabbit polyclonal anti-RAB24 for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. Use at a dilution of 1:300 to 1: 2000. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | RAB24 |
| Gene ID | 53917 |
| Uniprot ID | RAB24_HUMAN |
| Immunogen | A synthetic peptidefrom human RAB24 conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in mouse and rat. |
| Specificity | Specific for RAB24. |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction. |
| Protein Name | Ras-Related Protein Rab-24 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8873719 |
| Cellular Localisation | CytoplasmCytosolMembraneLipid-AnchorCytoplasmic VesicleAutophagosome MembranePerinuclear RegionCytoskeletonSpindleOnly About 20% Is Recovered In The Particulate FractionRab24 Localizes In Perinuclear Region And In The Limiting Membranes Of Autophagic Compartments Under Basal ConditionsRab24 Is Localized In The Cytoplasm With An Accumulated Distribution In Nuclear Region At Germinal Vesicle (Gv) Stage Of Oocyte Meiotic ProgressionAt Pre-Metaphase I StageLocalized In The Cytoplasm With A Particular Concentration Around ChromosomesAs The Oocytes Enter Metaphase ILocated To The Spindle RegionSimilar Distribution Pattern Is Observed In Mii Oocytes |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-24 antibodyAnti-RAB24 antibody |
Information sourced from Uniprot.org