Anti-RAB18 antibody (1-206) (STJ25256)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RAB18 (1-206) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB18 |
| Gene ID | 22931 |
| Uniprot ID | RAB18_HUMAN |
| Immunogen Region | 1-206 |
| Immunogen Sequence | MDEDVLTTLKILIIGESGVG KSSLLLRFTDDTFDPELAAT IGVDFKVKTISVDGNKAKLA IWDTAGQERFRTLTPSYYRG AQGVILVYDVTRRDTFVKLD NWLNELETYCTRNDIVNMLV GNKIDKENREVDRNEGLKFA RKHSMLFIEASAKTCDGVQC AFEELVEKIIQTPGLWESEN QNKGVKLSHREEGQGGGACG GYCSVL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-206 of human RAB18 (NP_067075.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB18 is required for the localization of ZFYVE1 to lipid droplets and for its function in mediating the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts. Also required for maintaining endoplasmic reticulum structure. Plays a role in apical endocytosis/recycling. Plays a key role in eye and brain development and neurodegeneration. |
| Protein Name | Ras-Related Protein Rab-18 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-6811436Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Endoplasmic Reticulum MembraneGolgi ApparatusCis-Golgi Network MembraneLipid DropletApical Cell MembraneLocalized To The Er Membrane As Well As To The Cis-Golgi In Fibroblasts |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-18 antibodyAnti-RAB18 antibody |
Information sourced from Uniprot.org