Anti-Rab17-Mouse antibody (Internal) (STJ71451)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Rab17-Mouse (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 23kDa band observed in Mouse Kidney lysates (calculated MW of 23.6kDa according to NP_033024.1). Recommended concentration: 0.2-0.6µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Accession Number | NP_033024.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | RKDSFHKAQQWLED |
| Specificity | Reported variants represent identical protein (NP_001153197.2; NP_033024.1). |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration. |
| Protein Name | Ras-Related Protein Rab-17 |
| Database Links | Reactome: R-MMU-8873719 |
| Cellular Localisation | Recycling Endosome MembraneLipid-AnchorCytoplasmic SideMelanosomeCell ProjectionDendriteAccording To A Report The Protein Is Localized At The Basolateral And Apical Plasma Membrane Of Kidney Epithelial CellsIt Was Later Shown To Localize To The Apical Recycling Endosome In Epithelial CellsIn NeuronsLocalizes To The Cell Body And Dendritic Shaft And Spine |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-17 antibodyAnti-Rab17 antibody |
Information sourced from Uniprot.org