Anti-RAB17 antibody (1-212) (STJ110141)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RAB17 (1-212) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB17 |
| Gene ID | 64284 |
| Uniprot ID | RAB17_HUMAN |
| Immunogen Region | 1-212 |
| Immunogen Sequence | MAQAHRTPQPRAAPSQPRVF KLVLLGSGSVGKSSLALRYV KNDFKSILPTVGCAFFTKVV DVGATSLKLEIWDTAGQEKY HSVCHLYFRGANAALLVYDI TRKDSFLKAQQWLKDLEEEL HPGEVLVMLVGNKTDLSQER EVTFQEGKEFADSQKLLFME TSAKLNHQVSEVFNTVAQEL LQRSDEEGQALRGDAAVALN KGPARQAKCCAH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human RAB17 (NP_071894.1). |
Additional Info
| Tissue Specificity | Expressed in melanocytes (at protein level). |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB17 is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration. |
| Protein Name | Ras-Related Protein Rab-17 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Recycling Endosome MembraneLipid-AnchorCytoplasmic SideMelanosomeCell ProjectionDendriteMay Also Localize At The Basolateral And Apical Plasma MembraneIn NeuronsLocalizes To The Cell Body And Dendritic Shaft And Spine |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-17 antibodyAnti-RAB17 antibody |
Information sourced from Uniprot.org