| Short Description : | Rabbit polyclonal anti-Ras-related protein Rab-12 (186-236 aa) for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAB12 |
| Gene ID: | 201475 |
| Uniprot ID: | RAB12_HUMAN |
| Immunogen: | Synthesized peptide derived from the human RAB12 at the amino acid range 186-236 |
| Immunogen Region: | 186-236 aa |
| Specificity: | This antibody detects endogenous levels of RAB12 at Human/Mouse/Rat |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy. |
| Protein Name | Ras-Related Protein Rab-12 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Recycling Endosome MembraneLipid-AnchorCytoplasmic SideLysosome MembraneGolgi Apparatus MembraneCytoplasmic VesicleAutophagosome |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-12 antibodyAnti-RAB12 antibody |
Information sourced from Uniprot.org
