Anti-Pyruvate Dehydrogenase E2 antibody [R01-6I2] (STJA0035341)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Pyruvate Dehydrogenase E2
General Information
| Short Description | Rabbit monoclonal anti-Pyruvate Dehydrogenase E2 for use in WB, ICC, IF and IP in Human, Mouse, Rat and Hamster samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Hamster |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-6I2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | DLAT |
| Gene ID | 1737 |
| Uniprot ID | ODP2_HUMAN |
| Immunogen | A synthetic peptide of human Pyruvate Dehydrogenase E2 |
Additional Info
| Post Translational Modifications | Delipoylated at Lys-132 and Lys-259 by SIRT4, delipoylation decreases the PHD complex activity. |
| Function | As part of the pyruvate dehydrogenase complex, catalyzes the transfers of an acetyl group to a lipoic acid moiety (Probable). The pyruvate dehydrogenase complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle (Probable). |
| Protein Name | Dihydrolipoyllysine-Residue Acetyltransferase Component Of Pyruvate Dehydrogenase Complex - Mitochondrial70 Kda Mitochondrial Autoantigen Of Primary Biliary CirrhosisPbcDihydrolipoamide Acetyltransferase Component Of Pyruvate Dehydrogenase ComplexM2 Antigen Complex 70 Kda SubunitPyruvate Dehydrogenase Complex Component E2Pdc-E2Pdce2 |
| Database Links | Reactome: R-HSA-204174Reactome: R-HSA-5362517Reactome: R-HSA-9857492Reactome: R-HSA-9861559 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Dihydrolipoyllysine-Residue Acetyltransferase Component Of Pyruvate Dehydrogenase Complex - Mitochondrial antibodyAnti-70 Kda Mitochondrial Autoantigen Of Primary Biliary Cirrhosis antibodyAnti-Pbc antibodyAnti-Dihydrolipoamide Acetyltransferase Component Of Pyruvate Dehydrogenase Complex antibodyAnti-M2 Antigen Complex 70 Kda Subunit antibodyAnti-Pyruvate Dehydrogenase Complex Component E2 antibodyAnti-Pdc-E2 antibodyAnti-Pdce2 antibodyAnti-DLAT antibodyAnti-DLTA antibody |
Information sourced from Uniprot.org