Immunohistochemical analysis of paraffin-embedded human Squamous cell carcinoma of lung. 1, Antibody was diluted at 1:200 (4ยฐC overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-PYDC1 antibody (25-75 aa) (STJ196561)

⇓ Datasheet ⇓ SDS
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human PYDC1 at the amino acid range 25-75
STJ196561
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General Information

Short DescriptionRabbit polyclonal anti-Pyrin domain-containing protein 1 (25-75 aa) for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents.
ApplicationsIHC/IF
HostRabbit
ReactivityHuman/Rat/Mouse
NoteSTRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

ClonalityPolyclonal
IsotypeIgG
ConjugationUnconjugated
Concentration1 mg/mL
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution RangeIHC-P 1:50-200
IF 1:50-200
FormulationLiquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage InstructionStore at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Target Information

Gene SymbolPYDC1
Gene ID260434
Uniprot IDPYDC1_HUMAN
ImmunogenSynthesized peptide derived from the human PYDC1 at the amino acid range 25-75
Immunogen Region25-75 aa
SpecificityThis antibody detects endogenous levels of PYDC1 at Human

Additional Info

Post Translational Modifications Phosphorylated.
Function Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Protein Name Pyrin Domain-Containing Protein 1
Paad-Only Protein 1
Pyrin-Only Protein 1
Cellular Pop1
Cpop1
Database Links
Cellular Localisation Cytoplasm
Recruited To Specks Formed By Pycard Within The Cytoplasm
Alternative Antibody Names Anti-Pyrin Domain-Containing Protein 1 antibody
Anti-Paad-Only Protein 1 antibody
Anti-Pyrin-Only Protein 1 antibody
Anti-Cellular Pop1 antibody
Anti-Cpop1 antibody
Anti-PYDC1 antibody
Anti-ASC2 antibody
Anti-ASCI antibody
Anti-POP1 antibody
Anti-PYC1 antibody

Information sourced from Uniprot.org

Citations

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