| Host: |
Rabbit |
| Applications: |
WB/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Poliovirus receptor (81-130 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IF 1:100-300ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PVR |
| Gene ID: |
5817 |
| Uniprot ID: |
PVR_HUMAN |
| Immunogen Region: |
81-130 aa |
| Specificity: |
CD155 Polyclonal Antibody detects endogenous levels of CD155 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human PVR at the amino acid range 81-130 |
| Function | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. |
| Protein Name | Poliovirus ReceptorNectin-Like Protein 5Necl-5Cd Antigen Cd155 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-420597 |
| Cellular Localisation | Isoform Alpha: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Delta: Cell MembraneIsoform Beta: SecretedIsoform Gamma: Secreted |
| Alternative Antibody Names | Anti-Poliovirus Receptor antibodyAnti-Nectin-Like Protein 5 antibodyAnti-Necl-5 antibodyAnti-Cd Antigen Cd155 antibodyAnti-PVR antibodyAnti-PVS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
