Anti-PUS1 antibody (STJA0008127)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PUS1
General Information
| Short Description | Rabbit polyclonal anti-Pseudouridylate synthase 1 homolog synthase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PUS1 |
| Gene ID | 80324 |
| Uniprot ID | PUS1_HUMAN |
| Immunogen | Synthesized peptide derived from human PUS1 |
| Specificity | This antibody detects endogenous levels of PUS1 at Human, Mouse, Rat |
Additional Info
| Function | Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA. |
| Protein Name | Pseudouridylate Synthase 1 HomologTrna Pseudouridine Synthase 1Trna Pseudouridine(38-40 SynthaseTrna Pseudouridylate Synthase ITrna-Uridine Isomerase I |
| Database Links | Reactome: R-HSA-6782315 Q9Y606-2Reactome: R-HSA-6787450 Q9Y606-1 |
| Cellular Localisation | Isoform 1: MitochondrionIsoform 2: NucleusCytoplasm |
| Alternative Antibody Names | Anti-Pseudouridylate Synthase 1 Homolog antibodyAnti-Trna Pseudouridine Synthase 1 antibodyAnti-Trna Pseudouridine(38-40 Synthase antibodyAnti-Trna Pseudouridylate Synthase I antibodyAnti-Trna-Uridine Isomerase I antibodyAnti-PUS1 antibodyAnti-PP8985 antibody |
Information sourced from Uniprot.org