Anti-PUS1 antibody [R02-0A2] (STJA0034777)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein of human PUS1
General Information
| Short Description | Rabbit monoclonal anti-PUS1 for use in WB, ICC, IF and IP in Human, Hamster and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Hamster/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-0A2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | PUS1 |
| Gene ID | 80324 |
| Uniprot ID | PUS1_HUMAN |
| Immunogen | Recombinant protein of human PUS1 |
Additional Info
| Tissue Specificity | Widely expressed. High levels of expression found in brain and skeletal muscle. |
| Function | Pseudouridylate synthase that catalyzes pseudouridylation of tRNAs and mRNAs. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. Acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. Involved in regulation of nuclear receptor activity through pseudouridylation of SRA1 mRNA. |
| Protein Name | Pseudouridylate Synthase 1 HomologTrna Pseudouridine Synthase 1Trna Pseudouridine(38-40 SynthaseTrna Pseudouridylate Synthase ITrna-Uridine Isomerase I |
| Database Links | Reactome: R-HSA-6782315 Q9Y606-2Reactome: R-HSA-6787450 Q9Y606-1 |
| Cellular Localisation | Isoform 1: MitochondrionIsoform 2: NucleusCytoplasm |
| Alternative Antibody Names | Anti-Pseudouridylate Synthase 1 Homolog antibodyAnti-Trna Pseudouridine Synthase 1 antibodyAnti-Trna Pseudouridine(38-40 Synthase antibodyAnti-Trna Pseudouridylate Synthase I antibodyAnti-Trna-Uridine Isomerase I antibodyAnti-PUS1 antibodyAnti-PP8985 antibody |
Information sourced from Uniprot.org