Anti-PTPRU antibody (270-350 aa) (STJ191303)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 270-350
General Information
| Short Description | Rabbit polyclonal anti-Receptor-type tyrosine-protein phosphatase U (270-350 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTPRU |
| Gene ID | 10076 |
| Uniprot ID | PTPRU_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 270-350 |
| Immunogen Region | 270-350 aa |
| Specificity | PTPRU Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed. N-glycosylated. Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated. |
| Function | Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase UR-Ptp-UPancreatic Carcinoma Phosphatase 2Pcp-2Protein-Tyrosine Phosphatase JPtp-JHptp-JProtein-Tyrosine Phosphatase PiPtp PiProtein-Tyrosine Phosphatase Receptor OmicronPtp-RoReceptor-Type Protein-Tyrosine Phosphatase PsiR-Ptp-Psi |
| Database Links | Reactome: R-HSA-1433557 |
| Cellular Localisation | Cell JunctionCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase U antibodyAnti-R-Ptp-U antibodyAnti-Pancreatic Carcinoma Phosphatase 2 antibodyAnti-Pcp-2 antibodyAnti-Protein-Tyrosine Phosphatase J antibodyAnti-Ptp-J antibodyAnti-Hptp-J antibodyAnti-Protein-Tyrosine Phosphatase Pi antibodyAnti-Ptp Pi antibodyAnti-Protein-Tyrosine Phosphatase Receptor Omicron antibodyAnti-Ptp-Ro antibodyAnti-Receptor-Type Protein-Tyrosine Phosphatase Psi antibodyAnti-R-Ptp-Psi antibodyAnti-PTPRU antibodyAnti-FMI antibodyAnti-PCP2 antibodyAnti-PTPRO antibody |
Information sourced from Uniprot.org