| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Receptor-type tyrosine-protein phosphatase U (270-350 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTPRU |
| Gene ID: |
10076 |
| Uniprot ID: |
PTPRU_HUMAN |
| Immunogen Region: |
270-350 aa |
| Specificity: |
PTPRU Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 270-350 |
| Post Translational Modifications | The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed. N-glycosylated. Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated. |
| Function | Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase UR-Ptp-UPancreatic Carcinoma Phosphatase 2Pcp-2Protein-Tyrosine Phosphatase JPtp-JHptp-JProtein-Tyrosine Phosphatase PiPtp PiProtein-Tyrosine Phosphatase Receptor OmicronPtp-RoReceptor-Type Protein-Tyrosine Phosphatase PsiR-Ptp-Psi |
| Database Links | Reactome: R-HSA-1433557 |
| Cellular Localisation | Cell JunctionCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase U antibodyAnti-R-Ptp-U antibodyAnti-Pancreatic Carcinoma Phosphatase 2 antibodyAnti-Pcp-2 antibodyAnti-Protein-Tyrosine Phosphatase J antibodyAnti-Ptp-J antibodyAnti-Hptp-J antibodyAnti-Protein-Tyrosine Phosphatase Pi antibodyAnti-Ptp Pi antibodyAnti-Protein-Tyrosine Phosphatase Receptor Omicron antibodyAnti-Ptp-Ro antibodyAnti-Receptor-Type Protein-Tyrosine Phosphatase Psi antibodyAnti-R-Ptp-Psi antibodyAnti-PTPRU antibodyAnti-FMI antibodyAnti-PCP2 antibodyAnti-PTPRO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
