Anti-PTPRS antibody (320-400 aa) (STJ191301)

SKU:
STJ191301

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Receptor-type tyrosine-protein phosphatase S (320-400 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTPRS
Gene ID: 5802
Uniprot ID: PTPRS_HUMAN
Immunogen Region: 320-400 aa
Specificity: PTPRS Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 320-400
Post Translational Modifications A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.
Function Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase S
R-Ptp-S
Receptor-Type Tyrosine-Protein Phosphatase Sigma
R-Ptp-Sigma
Database Links Reactome: R-HSA-3000178
Reactome: R-HSA-388844
Reactome: R-HSA-8849932
Reactome: R-HSA-9034015
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Axon
Perikaryon
Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Synapse
Synaptosome
Postsynaptic Density
Neuron Projection
Growth Cone
Is Rapidly Internalized When Dendritic Cells Are Stimulated With The Tlr9 Ligand Cytidine-Phosphate-Guanosine (Cpg)
Detected In A Punctate Pattern Along Neurites And Axon Growth Cones
Alternative Antibody Names Anti-Receptor-Type Tyrosine-Protein Phosphatase S antibody
Anti-R-Ptp-S antibody
Anti-Receptor-Type Tyrosine-Protein Phosphatase Sigma antibody
Anti-R-Ptp-Sigma antibody
Anti-PTPRS antibody

Information sourced from Uniprot.org

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