Anti-PTPRR protein isoforms antibody [6A6] (STJ16100949)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2
ImmunogenRecombinant PTP-SL-GST (NCBI accession number BN000437
General Information
| Short Description | Mouse monoclonal anti-PTPRR protein isoforms for use in IHC, WB and IP in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB/IP |
| Host | Mouse |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 6A6 |
| Isotype | IgG2 |
| Conjugation | Unconjugated |
| Formulation | lyophilized in a 10 mM ammonium bicarbonate buffer. Each vial contains 2 mg BSA |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | PTPRR |
| Gene ID | 5801 |
| Uniprot ID | PTPRR_HUMAN |
| Immunogen | Recombinant PTP-SL-GST (NCBI accession number BN000437 |
Additional Info
| Tissue Specificity | Detected in cerebrospinal fluid (at protein level). Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus. |
| Function | Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase RR-Ptp-RCh-1ptpaseNc-Ptpcom1Protein-Tyrosine Phosphatase Pcptp1 |
| Database Links | |
| Cellular Localisation | SecretedIsoform Alpha: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Delta: CytoplasmPerinuclear RegionLocates To The Perinuclear Areas Within The CytoplasmIsoform Gamma: Cytoplasm |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase R antibodyAnti-R-Ptp-R antibodyAnti-Ch-1ptpase antibodyAnti-Nc-Ptpcom1 antibodyAnti-Protein-Tyrosine Phosphatase Pcptp1 antibodyAnti-PTPRR antibodyAnti-ECPTP antibodyAnti-PTPRQ antibody |
Information sourced from Uniprot.org