Anti-PTPN5 antibody (190-307) (STJ119012)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PTPN5 (190-307) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTPN5 |
| Gene ID | 84867 |
| Uniprot ID | PTN5_HUMAN |
| Immunogen Region | 190-307 |
| Immunogen Sequence | SFTYSEWMEEKIEDDFLDLD PVPETPVFDCVMDIKPEADP TSLTVKSMGLQERRGSNVSL TLDMCTPGCNEEGFGYLMSP REESAREYLLSASRVLQAEE LHEKALDPFLLQAEFFEI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 190-307 of human PTPN5 (NP_116170.3). |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase. |
| Function | May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 5Neural-Specific Protein-Tyrosine PhosphataseStriatum-Enriched Protein-Tyrosine PhosphataseStep |
| Database Links | Reactome: R-HSA-9008059 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 5 antibodyAnti-Neural-Specific Protein-Tyrosine Phosphatase antibodyAnti-Striatum-Enriched Protein-Tyrosine Phosphatase antibodyAnti-Step antibodyAnti-PTPN5 antibody |
Information sourced from Uniprot.org