| Short Description : | Rabbit polyclonal anti-Tyrosine-protein phosphatase non-receptor type 4 (496-546 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPN4 |
| Gene ID: | 5775 |
| Uniprot ID: | PTN4_HUMAN |
| Immunogen: | Synthesized peptide derived from the human PTN4 at the amino acid range 496-546 |
| Immunogen Region: | 496-546 aa |
| Specificity: | This antibody detects endogenous levels of PTN4 at Human/Mouse |
| Function | Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis. Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Also dephosphorylates the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membrane and the cytoskeleton. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 4Protein-Tyrosine Phosphatase Meg1MegPtpase-Meg1 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-9008059Reactome: R-HSA-9022699 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 4 antibodyAnti-Protein-Tyrosine Phosphatase Meg1 antibodyAnti-Meg antibodyAnti-Ptpase-Meg1 antibodyAnti-PTPN4 antibody |
Information sourced from Uniprot.org
