| Short Description : | Rabbit polyclonal anti-Tyrosine-protein phosphatase non-receptor type 12 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPN12 |
| Gene ID: | 5782 |
| Uniprot ID: | PTN12_HUMAN |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Specificity: | PTN12 Polyclonal Antibody detects endogenous levels of protein. |
| Function | Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 12Ptp-PestProtein-Tyrosine Phosphatase G1Ptpg1 |
| Database Links | Reactome: R-HSA-1250196Reactome: R-HSA-182971Reactome: R-HSA-186797Reactome: R-HSA-8863795Reactome: R-HSA-9008059Reactome: R-HSA-9634285 |
| Cellular Localisation | CytoplasmCell JunctionFocal AdhesionCell ProjectionPodosomePartial Translocation To Focal Adhesion Sites May Be Mediated By Interaction With Sorbs2 |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 12 antibodyAnti-Ptp-Pest antibodyAnti-Protein-Tyrosine Phosphatase G1 antibodyAnti-Ptpg1 antibodyAnti-PTPN12 antibody |
Information sourced from Uniprot.org
