Anti-PTP4A2 antibody (30-100) (STJ117530)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PTP4A2 (30-100) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTP4A2 |
| Gene ID | 8073 |
| Uniprot ID | TP4A2_HUMAN |
| Immunogen Region | 30-100 |
| Immunogen Sequence | FTEELKKYGVTTLVRVCDAT YDKAPVEKEGIHVLDWPFDD GAPPPNQIVDDWLNLLKTKF REEPGCCVAVH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 30-100 of human PTP4A2 (NP_536316.1). |
Additional Info
| Tissue Specificity | Ubiquitously expressed, with highest levels in skeletal muscle, heart and thymus. Overexpressed in prostate tumor tissue. |
| Post Translational Modifications | Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB. Unfarnesylated forms are redirected to the nucleus and cytosol. |
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. |
| Protein Name | Protein Tyrosine Phosphatase Type Iva 2Hu-Pp-1Ov-1Ptp(CaaxiiProtein-Tyrosine Phosphatase 4a2Protein-Tyrosine Phosphatase Of Regenerating Liver 2Prl-2 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Cell MembraneEarly EndosomeCytoplasm |
| Alternative Antibody Names | Anti-Protein Tyrosine Phosphatase Type Iva 2 antibodyAnti-Hu-Pp-1 antibodyAnti-Ov-1 antibodyAnti-Ptp(Caaxii antibodyAnti-Protein-Tyrosine Phosphatase 4a2 antibodyAnti-Protein-Tyrosine Phosphatase Of Regenerating Liver 2 antibodyAnti-Prl-2 antibodyAnti-PTP4A2 antibodyAnti-PRL2 antibodyAnti-PTPCAAX2 antibodyAnti-BM-008 antibody |
Information sourced from Uniprot.org