Anti-PTK7 antibody [4F9] (STJ97900)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of human CCK-4 expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Inactive tyrosine-protein kinase 7 for use in WB, IHC, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4F9 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000IHC 1:200-1:1000ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTK7 |
| Gene ID | 5754 |
| Uniprot ID | PTK7_HUMAN |
| Immunogen | Purified recombinant fragment of human CCK-4 expressed in E. Coli. |
| Specificity | CCK-4 Monoclonal Antibody detects endogenous levels of CCK-4 protein. |
Additional Info
| Post Translational Modifications | MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment. Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway. |
| Function | Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. |
| Protein Name | Inactive Tyrosine-Protein Kinase 7Colon Carcinoma Kinase 4Cck-4Protein-Tyrosine Kinase 7Pseudo Tyrosine Kinase Receptor 7Tyrosine-Protein Kinase-Like 7 |
| Database Links | |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell JunctionColocalizes With Mmp14 At Cell JunctionsAlso Localizes At The Leading Edge Of Migrating Cells |
| Alternative Antibody Names | Anti-Inactive Tyrosine-Protein Kinase 7 antibodyAnti-Colon Carcinoma Kinase 4 antibodyAnti-Cck-4 antibodyAnti-Protein-Tyrosine Kinase 7 antibodyAnti-Pseudo Tyrosine Kinase Receptor 7 antibodyAnti-Tyrosine-Protein Kinase-Like 7 antibodyAnti-PTK7 antibodyAnti-CCK4 antibody |
Information sourced from Uniprot.org