Anti-PTHrP/PTHLH antibody (1-34aa) [SAA0326] (STJA0019249)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
General Information
| Short Description | Mouse monoclonal Parathyroid Hormone-Related Protein (1-34aa) antibody for use in Neut and WB in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | Neut/WB |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0326 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | PTHLH |
| Gene ID | 5744 |
| Uniprot ID | PTHR_HUMAN |
| Immunogen Region | 1-34aa |
Additional Info
| Post Translational Modifications | There are 3 principal secretory forms, called PTHrP1-36, PTHrP38-94, and osteostatin (PTHrP107-139) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. |
| Function | Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1. Osteostatin: Potent inhibitor of osteoclastic bone resorption. |
| Protein Name | Parathyroid Hormone-Related ProteinPth-RpPthrpParathyroid Hormone-Like ProteinPlp Cleaved Into - Pthrp1-36 - Pthrp38-94 - OsteostatinPthrp107-139 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | SecretedCytoplasmNucleus |
| Alternative Antibody Names | Anti-Parathyroid Hormone-Related Protein antibodyAnti-Pth-Rp antibodyAnti-Pthrp antibodyAnti-Parathyroid Hormone-Like Protein antibodyAnti-Plp Cleaved Into - Pthrp1-36 - Pthrp38-94 - Osteostatin antibodyAnti-Pthrp107-139 antibodyAnti-PTHLH antibodyAnti-PTHRP antibody |
Information sourced from Uniprot.org