| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTHLH (25-175) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:2000-1:9000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTHLH |
| Gene ID: |
5744 |
| Uniprot ID: |
PTHR_HUMAN |
| Immunogen Region: |
25-175 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-175 of human PTHLH (NP_945316.1). |
| Immunogen Sequence: |
GRSVEGLSRRLKRAVSEHQL LHDKGKSIQDLRRRFFLHHL IAEIHTAEIRATSEVSPNSK PSPNTKNHPVRFGSDDEGRY LTQETNKVETYKEQPLKTPG KKKKGKPGKRKEQEKKKRRT RSAWLDSGVTGSGLEGDHLS DTSTTSLELDSR |
| Tissue Specificity | Ubiquitous. Also expressed in the mammary gland. |
| Post Translational Modifications | There are 3 principal secretory forms, called PTHrP1-36, PTHrP38-94, and osteostatin (PTHrP107-139) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. |
| Function | Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1. Osteostatin is a potent inhibitor of osteoclastic bone resorption. |
| Protein Name | Parathyroid Hormone-Related ProteinPth-RpPthrpParathyroid Hormone-Like ProteinPlp Cleaved Into - Pthrp1-36 - Pthrp38-94 - OsteostatinPthrp107-139 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | CytoplasmNucleusSecreted |
| Alternative Antibody Names | Anti-Parathyroid Hormone-Related Protein antibodyAnti-Pth-Rp antibodyAnti-Pthrp antibodyAnti-Parathyroid Hormone-Like Protein antibodyAnti-Plp Cleaved Into - Pthrp1-36 - Pthrp38-94 - Osteostatin antibodyAnti-Pthrp107-139 antibodyAnti-PTHLH antibodyAnti-PTHRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
