• Western blot analysis of Hela cells using PTH-rP Polyclonal Antibody diluted at 1:800. Secondary antibody was diluted at 1:20000

Anti-PTHLH antibody (101-150 aa) (STJ98621)

SKU:
STJ98621

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody Anti-Parathyroid hormone-related protein (101-150 aa) is suitable for use in Western Blot and ELISA.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Concentration: 1 mg/ml
Dilution Range: WB 1:500-2000
ELISA 1:10000-20000
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTHLH
Gene ID: 5744
Uniprot ID: PTHR_HUMAN
Immunogen Region: 101-150 aa
Specificity: PTH-rP polyclonal antibody detects endogenous levels of PTH-rP
Immunogen: Synthesized peptide derived from PTH-rP
Post Translational Modifications There are 3 principal secretory forms, called PTHrP1-36, PTHrP38-94, and osteostatin (PTHrP107-139) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.
Function Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath. Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1. Osteostatin is a potent inhibitor of osteoclastic bone resorption.
Protein Name Parathyroid Hormone-Related Protein
Pth-Rp
Pthrp
Parathyroid Hormone-Like Protein
Plp Cleaved Into - Pthrp1-36 - Pthrp38-94 - Osteostatin
Pthrp107-139
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-418555
Reactome: R-HSA-9660821
Cellular Localisation Cytoplasm
Nucleus
Secreted
Alternative Antibody Names Anti-Parathyroid Hormone-Related Protein antibody
Anti-Pth-Rp antibody
Anti-Pthrp antibody
Anti-Parathyroid Hormone-Like Protein antibody
Anti-Plp Cleaved Into - Pthrp1-36 - Pthrp38-94 - Osteostatin antibody
Anti-Pthrp107-139 antibody
Anti-PTHLH antibody
Anti-PTHRP antibody

Information sourced from Uniprot.org

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