![Anti-PTH1R nanobody [SAA1275] (STJN000255)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200868/413050/STJN000255-SDS-PAGE-1__60536.1749232561.jpg?c=1 "Anti-PTH1R nanobody [SAA1275] (STJN000255)")
![Anti-PTH1R nanobody [SAA1275] (STJN000255)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200868/413050/STJN000255-SDS-PAGE-1__60536.1749232561.jpg?c=1 "Anti-PTH1R nanobody [SAA1275] (STJN000255)")
Anti-PTH1R nanobody [SAA1275] (STJN000255)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor is suitable for use in ELISA and RIA research applications. |
| Applications | ELISA/RIA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1275 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | PTH1R |
| Gene ID | 5745 |
| Uniprot ID | PTH1R_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH.as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH. |
| Protein Name | Parathyroid Hormone/Parathyroid Hormone-Related Peptide ReceptorPth/Pthrp Type I ReceptorPth/Pthr ReceptorParathyroid Hormone 1 ReceptorPth1 Receptor |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor nanobodyAnti-Pth/Pthrp Type I Receptor nanobodyAnti-Pth/Pthr Receptor nanobodyAnti-Parathyroid Hormone 1 Receptor nanobodyAnti-Pth1 Receptor nanobodyAnti-PTH1R nanobodyAnti-PTHR nanobodyAnti-PTHR1 nanobody |
Information sourced from Uniprot.org