![Anti-PTH1R nanobody [SAA0797] (STJN000011)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200624/412806/STJN000011-SDS-PAGE-1__84199.1749232361.jpg?c=1 "Anti-PTH1R nanobody [SAA0797] (STJN000011)")
![Anti-PTH1R nanobody [SAA0797] (STJN000011)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200624/412806/STJN000011-SDS-PAGE-1__84199.1749232361.jpg?c=1 "Anti-PTH1R nanobody [SAA0797] (STJN000011)")
Anti-PTH1R nanobody [SAA0797] (STJN000011)
General Information
| Short Description | Alpaca monoclonal nanobody anti-Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor is suitable for use in ELISA and RIA research applications. |
| Applications | ELISA/RIA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0797 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | PTH1R |
| Gene ID | 5745 |
| Uniprot ID | PTH1R_HUMAN |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH.as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH. |
| Protein Name | Parathyroid Hormone/Parathyroid Hormone-Related Peptide ReceptorPth/Pthrp Type I ReceptorPth/Pthr ReceptorParathyroid Hormone 1 ReceptorPth1 Receptor |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor nanobodyAnti-Pth/Pthrp Type I Receptor nanobodyAnti-Pth/Pthr Receptor nanobodyAnti-Parathyroid Hormone 1 Receptor nanobodyAnti-Pth1 Receptor nanobodyAnti-PTH1R nanobodyAnti-PTHR nanobodyAnti-PTHR1 nanobody |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Anti-PTH1R nanobody [SAA0797] (STJN000011)
This nanobody targets PTH1R (Parathyroid Hormone 1 Receptor, UniProt Q03431) and has confirmed reactivity against the human form of the protein. No cross-reactivity data for other species is provided.
This nanobody has been validated for use in ELISA and RIA. It is intended for research use only and has not been validated for diagnostic or therapeutic applications.
This nanobody is supplied in a VHH-8His-Cys-tag format and is unconjugated. The His-tag supports purification and detection workflows, while the Cys-tag can facilitate site-specific conjugation by the end user if required.
This nanobody was purified by Nickel column affinity chromatography and has a purity of greater than 95% as determined by SDS-PAGE. It is supplied at a concentration of 1 mg/mL in 0.01M PBS, pH 7.4.
For short-term storage of 1 to 2 weeks, the antibody should be kept at 4°C. For storage up to 12 months, store at -20°C, and for long-term storage, keep at -80°C. Repeated freeze-thaw cycles should be avoided, and a manual defrost freezer is recommended.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.