| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Parathyroid hormone/parathyroid hormone-related peptide receptor (145-194 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTH1R |
| Gene ID: | 5745 |
| Uniprot ID: | PTH1R_HUMAN |
| Immunogen Region: | 145-194 aa |
| Specificity: | PTH/PTHrP-R Polyclonal Antibody detects endogenous levels of PTH/PTHrP-R protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PTHR1 at the amino acid range 145-194 |
| Post Translational Modifications | N-glycosylated. |
| Function | G-protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. PTHLH dissociates from PTH1R more rapidly than PTH.as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH. |
| Protein Name | Parathyroid Hormone/Parathyroid Hormone-Related Peptide ReceptorPth/Pthrp Type I ReceptorPth/Pthr ReceptorParathyroid Hormone 1 ReceptorPth1 Receptor |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor antibodyAnti-Pth/Pthrp Type I Receptor antibodyAnti-Pth/Pthr Receptor antibodyAnti-Parathyroid Hormone 1 Receptor antibodyAnti-Pth1 Receptor antibodyAnti-PTH1R antibodyAnti-PTHR antibodyAnti-PTHR1 antibody |
Information sourced from Uniprot.org
