Anti-PTGR1 antibody (Internal) (STJ73202)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PTGR1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 37kDa band observed in Human Kidney lysates (calculated MW of 35.9kDa according to NP_036344.2). Recommended concentration: 0.3-1µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PTGR1 |
| Gene ID | 22949 |
| Uniprot ID | PTGR1_HUMAN |
| Accession Number | NP_036344.2; NP_001139581.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | PTNSDFELKTAELP |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_036344.2; NP_001139581.1). Reported variants represent identical protein: NP_036344.2, NP_001139580.1. |
Additional Info
| Function | NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles. |
| Protein Name | Prostaglandin Reductase 1Prg-115-Oxoprostaglandin 13-ReductaseDithiolethione-Inducible Gene 1 ProteinD3t-Inducible Gene 1 ProteinDig-1Leukotriene B4 12-HydroxydehydrogenaseNad(Ph-Dependent Alkenal/One Oxidoreductase |
| Database Links | Reactome: R-HSA-2142691Reactome: R-HSA-2142700 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Prostaglandin Reductase 1 antibodyAnti-Prg-1 antibodyAnti-15-Oxoprostaglandin 13-Reductase antibodyAnti-Dithiolethione-Inducible Gene 1 Protein antibodyAnti-D3t-Inducible Gene 1 Protein antibodyAnti-Dig-1 antibodyAnti-Leukotriene B4 12-Hydroxydehydrogenase antibodyAnti-Nad(Ph-Dependent Alkenal/One Oxidoreductase antibodyAnti-PTGR1 antibodyAnti-LTB4DH antibody |
Information sourced from Uniprot.org