Anti-PTGIS/CYP8A1 antibody (248-258) (STJ73226)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PTGIS/CYP8A1 (248-258) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 55kDa band observed in Human Lung and Human Ovary lysates (calculated MW of 57.1kDa according to NP_000952.1). Recommended concentration: 0.5-1.5µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PTGIS |
| Gene ID | 5740 |
| Uniprot ID | PTGIS_HUMAN |
| Accession Number | NP_000952.1 |
| Immunogen Region | 248-258 |
| Immunogen Sequence | RRAHRSKWLES |
Additional Info
| Function | Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE). |
| Protein Name | Prostacyclin SynthaseHydroperoxy Icosatetraenoate DehydrataseProstaglandin I2 Synthase |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-211979Reactome: R-HSA-2162123 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Prostacyclin Synthase antibodyAnti-Hydroperoxy Icosatetraenoate Dehydratase antibodyAnti-Prostaglandin I2 Synthase antibodyAnti-PTGIS antibodyAnti-CYP8 antibodyAnti-CYP8A1 antibody |
Information sourced from Uniprot.org