Anti-PTGES2 antibody (STJA0006972)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human PTGES2
General Information
| Short Description | Rabbit polyclonal anti-Prostaglandin E synthase 2 E-isomerase for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTGES2 |
| Gene ID | 80142 |
| Uniprot ID | PGES2_HUMAN |
| Immunogen | Synthesized peptide derived from human PTGES2 |
| Specificity | This antibody detects endogenous levels of PTGES2 at Human, Mouse |
Additional Info
| Post Translational Modifications | Synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. |
| Function | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA). |
| Protein Name | Prostaglandin E Synthase 2Membrane-Associated Prostaglandin E Synthase-2Mpge Synthase-2Microsomal Prostaglandin E Synthase 2Mpges-2Prostaglandin-H(2 E-Isomerase Cleaved Into - Prostaglandin E Synthase 2 Truncated Form |
| Database Links | Reactome: R-HSA-2162123Reactome: R-HSA-6798695 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Membrane ProteinProstaglandin E Synthase 2 Truncated Form: CytoplasmPerinuclear RegionSynthesized As A Golgi Membrane-Bound ProteinWhich Is Further Cleaved Into The Predominant Soluble Truncated FormThe Truncated Form Is Cytoplasmic And Is Enriched In The Perinuclear Region |
| Alternative Antibody Names | Anti-Prostaglandin E Synthase 2 antibodyAnti-Membrane-Associated Prostaglandin E Synthase-2 antibodyAnti-Mpge Synthase-2 antibodyAnti-Microsomal Prostaglandin E Synthase 2 antibodyAnti-Mpges-2 antibodyAnti-Prostaglandin-H(2 E-Isomerase Cleaved Into - Prostaglandin E Synthase 2 Truncated Form antibodyAnti-PTGES2 antibodyAnti-C9orf15 antibodyAnti-PGES2 antibody |
Information sourced from Uniprot.org