Anti-PTGES2 antibody (292-306) (STJ73191)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-PTGES2 (292-306) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 30kDa band observed in lysates of cell line HeLa (calculated MW of 41.9kDa according to NP_079348.1). This molecular weight is routinely observed by other sources. Recommended |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | PTGES2 |
| Gene ID | 80142 |
| Uniprot ID | PGES2_HUMAN |
| Accession Number | NP_079348.1; NP_945176.1 |
| Immunogen Region | 292-306 |
| Immunogen Sequence | RLKSRHRLQDNVRED |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_079348.1; NP_945176.1). Reported variants represent identical protein: NP_001243264.1, NP_945176.1. |
Additional Info
| Post Translational Modifications | Synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. |
| Function | Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA). |
| Protein Name | Prostaglandin E Synthase 2Membrane-Associated Prostaglandin E Synthase-2Mpge Synthase-2Microsomal Prostaglandin E Synthase 2Mpges-2Prostaglandin-H(2 E-Isomerase Cleaved Into - Prostaglandin E Synthase 2 Truncated Form |
| Database Links | Reactome: R-HSA-2162123Reactome: R-HSA-6798695 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Membrane ProteinProstaglandin E Synthase 2 Truncated Form: CytoplasmPerinuclear RegionSynthesized As A Golgi Membrane-Bound ProteinWhich Is Further Cleaved Into The Predominant Soluble Truncated FormThe Truncated Form Is Cytoplasmic And Is Enriched In The Perinuclear Region |
| Alternative Antibody Names | Anti-Prostaglandin E Synthase 2 antibodyAnti-Membrane-Associated Prostaglandin E Synthase-2 antibodyAnti-Mpge Synthase-2 antibodyAnti-Microsomal Prostaglandin E Synthase 2 antibodyAnti-Mpges-2 antibodyAnti-Prostaglandin-H(2 E-Isomerase Cleaved Into - Prostaglandin E Synthase 2 Truncated Form antibodyAnti-PTGES2 antibodyAnti-C9orf15 antibodyAnti-PGES2 antibody |
Information sourced from Uniprot.org