Anti-PSPC1 antibody (1-70) (STJ116347)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PSPC1 (1-70) antibody for use in WB, IHC-P, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PSPC1 |
| Gene ID | 55269 |
| Uniprot ID | PSPC1_HUMAN |
| Immunogen Region | 1-70 |
| Immunogen Sequence | MMLRGNLKQVRIEKNPARLR ALESAVGESEPAAAAAMALA LAGEPAPPAPAPPEDHPDEE MGFTIDIKSF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human PSPC1 (NP_001035879.1). |
Additional Info
| Tissue Specificity | Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. |
| Function | RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
| Protein Name | Paraspeckle Component 1Paraspeckle Protein 1 |
| Database Links | |
| Cellular Localisation | Nucleus SpeckleNucleusNucleolusNucleus MatrixCytoplasmIn Punctate Subnuclear Structures Often Located Adjacent To Splicing SpecklesCalled ParaspecklesColocalizes With Nono And Sfpq In Paraspeckles And Perinucleolar Caps In An Rna-Dependent MannerMay Cycle Between Paraspeckles And NucleolusIn TelophaseWhen Daughter Nuclei FormLocalizes To Perinucleolar Caps |
| Alternative Antibody Names | Anti-Paraspeckle Component 1 antibodyAnti-Paraspeckle Protein 1 antibodyAnti-PSPC1 antibodyAnti-PSP1 antibody |
Information sourced from Uniprot.org