Anti-PSME3 antibody (STJ98526)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
ImmunogenPurified recombinant human PA28 Gamma protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-Proteasome activator complex subunit 3 for use in WB and IF in Human, Mouse, Dog and Pig samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Dog/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity purification |
| Dilution Range | WB 1:1000-1:2000IF 1:100-1:500 |
| Formulation | Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PSME3 |
| Gene ID | 10197 |
| Uniprot ID | PSME3_HUMAN |
| Immunogen | Purified recombinant human PA28 Gamma protein fragments expressed in E.coli. |
| Specificity | PA28 Gamma Monoclonal Antibody detects endogenous levels of PA28 Gamma protein. |
Additional Info
| Function | Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition. |
| Protein Name | Proteasome Activator Complex Subunit 311s Regulator Complex Subunit GammaReg-GammaActivator Of Multicatalytic Protease Subunit 3Ki Nuclear AutoantigenProteasome Activator 28 Subunit GammaPa28gPa28gamma |
| Database Links | Reactome: R-HSA-9907900 |
| Cellular Localisation | NucleusCytoplasmLocalizes To The Cytoplasm During Mitosis Following Nuclear Envelope Breakdown At This Distinct Stage Of The Cell Cycle Which Allows Its Interaction With Map3k3 Kinase |
| Alternative Antibody Names | Anti-Proteasome Activator Complex Subunit 3 antibodyAnti-11s Regulator Complex Subunit Gamma antibodyAnti-Reg-Gamma antibodyAnti-Activator Of Multicatalytic Protease Subunit 3 antibodyAnti-Ki Nuclear Autoantigen antibodyAnti-Proteasome Activator 28 Subunit Gamma antibodyAnti-Pa28g antibodyAnti-Pa28gamma antibodyAnti-PSME3 antibody |
Information sourced from Uniprot.org