Anti-PSMD4 antibody (250-350) [S8MR] (STJ11101918)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal PSMD4 (250-350) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S8MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PSMD4 |
| Gene ID | 5710 |
| Uniprot ID | PSMD4_HUMAN |
| Immunogen Region | 250-350 |
| Immunogen Sequence | TTGTEDSDDALLKMTISQQE FGRTGLPDLSSMTEEEQIAY AMQMSLQGAEFGQAESADID ASSAMDTSEPAKEEDDYDVM QDPEFLQSVLENLPGVDPNN E |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human PSMD4 (P55036). |
Additional Info
| Function | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. |
| Protein Name | 26s Proteasome Non-Atpase Regulatory Subunit 426s Proteasome Regulatory Subunit Rpn1026s Proteasome Regulatory Subunit S5aAntisecretory Factor 1AfAsfMultiubiquitin Chain-Binding Protein |
| Database Links | Reactome: R-HSA-9907900 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-26s Proteasome Non-Atpase Regulatory Subunit 4 antibodyAnti-26s Proteasome Regulatory Subunit Rpn10 antibodyAnti-26s Proteasome Regulatory Subunit S5a antibodyAnti-Antisecretory Factor 1 antibodyAnti-Af antibodyAnti-Asf antibodyAnti-Multiubiquitin Chain-Binding Protein antibodyAnti-PSMD4 antibodyAnti-MCB1 antibody |
Information sourced from Uniprot.org