Western blot analysis of extracts of various cell lines, using PSMC5 antibody (STJ115498) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Anti-PSMC5 antibody (127-406) (STJ115498)

Name: Anti-PSMC5 antibody (127-406) (STJ115498)
SKU: STJ115498
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ115498

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General Information

Short Description	Rabbit polyclonal PSMC5 (127-406) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Product Properties

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Target Information

Gene Symbol	PSMC5
Gene ID	5705
Uniprot ID	PRS8_HUMAN
Immunogen Region	127-406
Immunogen Sequence	LPNKVDPLVSLMMVEKVPDS TYEMIGGLDKQIKEIKEVIE LPVKHPELFEALGIAQPKGV LLYGPPGTGKTLLARAVAHH TDCTFIRVSGSELVQKFIGE GARMVRELFVMAREHAPSII FMDEIDSIGSSRLEGGSGGD SEVQRTMLELLNQLDGFEAT KNIKVIMATNRIDILDSALL RPGRIDRKIEFPPPNEEARL DILKIHSRKMNLTRGINLRK IAELMPGASGAEVKGVCTE
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 127-406 of human PSMC5 (NP_002796.4).

Additional Info

Function	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Protein Name	26s Proteasome Regulatory Subunit 8 26s Proteasome Aaa-Atpase Subunit Rpt6 Proteasome 26s Subunit Atpase 5 Proteasome Subunit P45 Thyroid Hormone Receptor-Interacting Protein 1 Trip1 P45/Sug
Database Links	Reactome: R-HSA-1169091 Reactome: R-HSA-1234176 Reactome: R-HSA-1236974 Reactome: R-HSA-1236978 Reactome: R-HSA-174084 Reactome: R-HSA-174113 Reactome: R-HSA-174154 Reactome: R-HSA-174178 Reactome: R-HSA-174184 Reactome: R-HSA-180534 Reactome: R-HSA-180585 Reactome: R-HSA-187577 Reactome: R-HSA-195253 Reactome: R-HSA-202424 Reactome: R-HSA-211733 Reactome: R-HSA-2467813 Reactome: R-HSA-2871837 Reactome: R-HSA-349425 Reactome: R-HSA-350562 Reactome: R-HSA-382556 Reactome: R-HSA-450408 Reactome: R-HSA-4608870 Reactome: R-HSA-4641257 Reactome: R-HSA-4641258 Reactome: R-HSA-5358346 Reactome: R-HSA-5362768 Reactome: R-HSA-5607761 Reactome: R-HSA-5607764 Reactome: R-HSA-5610780 Reactome: R-HSA-5610783 Reactome: R-HSA-5610785 Reactome: R-HSA-5632684 Reactome: R-HSA-5658442 Reactome: R-HSA-5668541 Reactome: R-HSA-5676590 Reactome: R-HSA-5678895 Reactome: R-HSA-5687128 Reactome: R-HSA-5689603 Reactome: R-HSA-5689880 Reactome: R-HSA-68867 Reactome: R-HSA-68949 Reactome: R-HSA-69017 Reactome: R-HSA-69481 Reactome: R-HSA-69601 Reactome: R-HSA-75815 Reactome: R-HSA-8852276 Reactome: R-HSA-8854050 Reactome: R-HSA-8939236 Reactome: R-HSA-8939902 Reactome: R-HSA-8941858 Reactome: R-HSA-8948751 Reactome: R-HSA-8951664 Reactome: R-HSA-9010553 Reactome: R-HSA-9020702 Reactome: R-HSA-9604323 Reactome: R-HSA-9755511 Reactome: R-HSA-9762114 Reactome: R-HSA-9824272 Reactome: R-HSA-983168 Reactome: R-HSA-9907900
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-26s Proteasome Regulatory Subunit 8 antibody Anti-26s Proteasome Aaa-Atpase Subunit Rpt6 antibody Anti-Proteasome 26s Subunit Atpase 5 antibody Anti-Proteasome Subunit P45 antibody Anti-Thyroid Hormone Receptor-Interacting Protein 1 antibody Anti-Trip1 antibody Anti-P45/Sug antibody Anti-PSMC5 antibody Anti-SUG1 antibody

Information sourced from Uniprot.org

Citations

View product citations for antibody STJ115498 on CiteAb