Anti-PSENEN antibody (1-101) (STJ117366)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PSENEN (1-101) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PSENEN |
| Gene ID | 55851 |
| Uniprot ID | PEN2_HUMAN |
| Immunogen Region | 1-101 |
| Immunogen Sequence | MNLERVSNEEKLNLCRKYYL GGFAFLPFLWLVNIFWFFRE AFLVPAYTEQSQIKGYVWRS AVGFLFWVIVLTSWITIFQI YRPRWGALGDYLSFTIPLGT P |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-101 of human PEN2/PSENEN (NP_758844.1). |
Additional Info
| Tissue Specificity | Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. |
| Function | Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. |
| Protein Name | Gamma-Secretase Subunit Pen-2Presenilin Enhancer Protein 2 |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-193692Reactome: R-HSA-205043Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-3928665Reactome: R-HSA-9013507Reactome: R-HSA-9013700Reactome: R-HSA-9017802Reactome: R-HSA-977225Reactome: R-HSA-9839383 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi ApparatusGolgi Stack MembraneCell MembraneMembranePredominantly Located In The Endoplasmic Reticulum And In The Cis-Golgi |
| Alternative Antibody Names | Anti-Gamma-Secretase Subunit Pen-2 antibodyAnti-Presenilin Enhancer Protein 2 antibodyAnti-PSENEN antibodyAnti-PEN2 antibodyAnti-MDS033 antibody |
Information sourced from Uniprot.org